We read with interest the study recently published by Tré-Hardy et al., who reported that Adverse Events (AEs) after the first dose of mRNA-1273/Moderna vaccine were greater in those previously infected with COVID-191. Their findings are consistent with other studies that suggest mRNA vaccines may cause more AEs in those with a history SARS-CoV-2 infection [2], [3], [4]. These results warrant further investigation into the effects of prior COVID-19 history on vaccine reactions, particularly whether time between previous infection and vaccination administration, or the presence of ‘Long-COVID’ [5], can predict AEs. This information is important, as it could identify individuals more likely to experience side effects to COVID-19 vaccines. Furthermore, there are implications regarding vaccine hesitancy, which is partially driven by fear of AEs [6]. As part of an observational study of COVID-19 outcomes in healthcare workers in North-East England, we evaluated AEs following first doses of BNT162b2/Pfizer vaccine, with reference to previous COVID-19 and Long-COVID.

Read the abstract at PubMed Central